Status:
UNKNOWN
Comparative Study Between Only Vaginal Misoprostol and Vaginal Misoprostol and Estradiol Cream
Lead Sponsor:
Ain Shams University
Conditions:
Cervix; Pregnancy
Eligibility:
FEMALE
20-39 years
Phase:
PHASE1
PHASE2
Brief Summary
To compare the safety and effectiveness of vaginal misoprostol with combined vaginal misoprostol and estradiol for induction of labour in unfavorable cervix
Detailed Description
Induction of labour (IOL) is the process of initiating contractions of pregnant persons who are currently not in labour, to help them achieve vaginal delivery within 24 to 48 hours. Cervical ripening ...
Eligibility Criteria
Inclusion
- Gestational age36:41 weeks.
- Singleton pregnancy.
- Absence of labour pain.
- Living fetus with cephalic presentation.
- Fetal weight \< 4 k.gs.
- No previous uterine surgical procedures.
- No liquor abnormalities.
- Bishop score \< 5.
Exclusion
- \- Multiple gestations. one of the contraindications of induction of labor as it may cause rupture of the uterus.
- Liquor abnormalities.one of contraindications of induction of labor as it may cause fetal distress.
- Abnormal umbilical artery Doppler indices or non-stress test as these indicate fetal distress.
- Fetal weight \> 4 kgs.as macrosomia is an indication of caesarean section for fear of shoulder dystocia .
- Previous uterine surgery.contraindication of labor induction for fear of rupture uterus.
- Asthmatic patient or women with allergy to prostaglandins or steroidal.
- Non-vertex presentation.contraindication of labor induction as it may cause rupture uterus.
- Fetal or maternal complications that might cause cesarean section.
- Intrauterine fetal death.often induction of labor in women with a dead fetus is performed before term when the uterus may be less responsive to uterotonics than it is at term and this will affect the results of the study
Key Trial Info
Start Date :
February 20 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 30 2022
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT05306405
Start Date
February 20 2022
End Date
August 30 2022
Last Update
April 1 2022
Active Locations (1)
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1
Ain Shams University
Cairo, Egypt