Status:
COMPLETED
IL-10, IL-12 and IL-18 Levels in the Gingival Crevicular Fluid of Patients With Periodontitis and Healthy Controls
Lead Sponsor:
Istanbul University
Conditions:
Periodontitis
Eligibility:
All Genders
18-65 years
Brief Summary
Periodontitis is a multifactorial chronic inflammatory disease characterized by the destruction of the tissues supporting the tooth. The incidence and rate of progression of periodontal destruction in...
Detailed Description
Interleukin-10 (IL-10) is one of the most potent anti-inflammatory cytokines, as it induces T cell anergy (non-responsiveness to an antigen) and reduces the production of some pro-inflammatory cytokin...
Eligibility Criteria
Inclusion
- Inclusion Criteria for grade B-C stage III-IV periodontitis group:
- 18-65 years old
- Not having any systemic disease (diseases that do not affect the periodontal status)
- Non-smoker
- Have not received antibiotic treatment and/or used immunosuppressant medication in the last 6 months
- Have not received any periodontal treatment in the last 6 months
- No pregnancy and lactation
- Not using any medication regularly
- Having at least 20 teeth
- Grade B-C stage III-IV periodontal disease according to the 2017 Classification of Periodontal and Peri-implant Diseases and Conditions
- Inclusion Criteria for periodontal healthy group:
- •In patients who applied to Istanbul University Faculty of Dentistry, Department of Periodontology, periodontally healthy individuals who do not meet the above disease criteria, who do not have a history of periodontitis in any way, will be included in the study. Consisted of individuals with clinically healthy gingiva on an intact periodontium who had a BOP score less than 10% and PD≤3mm, showed no attachment loss or radiographic bone loss.
- Exclusion Criteria:
- Those with systemic modifying disease affecting periodontal status
- Smoker
- Have received antibiotic therapy or immunosuppressive therapy in the last 6 months
- Previously received periodontal treatment in the last 6 months
- Pregnancy and breastfeeding status
- Regular use of drugs that will affect systemic health
Exclusion
Key Trial Info
Start Date :
April 15 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 30 2023
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05307068
Start Date
April 15 2022
End Date
June 30 2023
Last Update
October 2 2023
Active Locations (1)
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1
Istanbul University Faculty of Dentistry
Istanbul, Turkey (Türkiye)