Status:
RECRUITING
Cytokine Expression in Psoriasis Patients with and Without Joint Involvement
Lead Sponsor:
Poitiers University Hospital
Conditions:
Psoriasis
Psoriatic Arthritis
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
The objective of the resarch is to study the cytokine profile of patients with psoriatic arthritis and psoriasis in order to better understand the pathophysiology of the disease and the contribution o...
Detailed Description
Psoriatic arthritis and Cutaneous Psoriasis are polygenic inflammatory disorders with high burden on the quality of life of patients. Pathophysiology of those disease remain incompletely understood. R...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- For psoriasis patients :
- Age over 18 years old
- Signed informed consent
- 5 year old psoriasis at least
- At least one skin lesion over 2 cm
- Without any articular symptoms
- Without any DMARDs
- Without anticoagulant treatments or coagulation disease
- With normal articular and enthesis sonography
- For psoriatic arthritis patients :
- Age over 18 years old
- Signed informed consent
- Psoriatic arthritis according to CASPAR criteria
- Without any DMARDs
- Without anticoagulant treatments or coagulation disease
- With at least one synovitis at inclusion
- For controls
- Age and sex matched with a patient without any rheumatic or dermatologic medical conditions
- No treatment with corticosteroïds or non-steroïdial anti-inflammatory drugsAge over 18 years old
- Exclusion criteria:
- ▪ For psoriasis patients :
- Joint damage according to CASPAR criteria
- Echography activity in favor of chronic inflammatory rheumatism
- For patients and controls:
- Without social protection rights
- People under judiciary protection, of less than 18 years old, pregnant woman, breast feeding women, jailed patients.
Exclusion
Key Trial Info
Start Date :
August 17 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 18 2026
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05307809
Start Date
August 17 2022
End Date
August 18 2026
Last Update
September 4 2024
Active Locations (1)
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1
Chu Poitiers
Poitiers, France