Status:
ACTIVE_NOT_RECRUITING
Neoantigen Vaccine in Esophagus Cancer Patients Following Neoadjuvant Therapy and Surgical Resection
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University
Collaborating Sponsors:
Hangzhou Neoantigen Therapeutics Co., Ltd.
Conditions:
Resectable Esophageal Cancer
Eligibility:
All Genders
18-80 years
Phase:
PHASE1
Brief Summary
This research study is evaluating a new type of esophagus cancer vaccine called "Personalized Neoantigen Cancer Vaccine" as a possible treatment for esophagus cancer patients who have completed adjuva...
Detailed Description
It is known that cancer patients have mutations (changes in genetic material) that are specific to an individual patient and tumor. These mutations can cause the tumor cells to produce proteins that a...
Eligibility Criteria
Inclusion
- Must freely sign informed consent;
- Aged 18 to 80 years old;
- Histologically or cytologically confirmed diagnosis of esophagus cancer;
- ECOG score is 0 or 1;
- completed Neoadjuvant combined with PD-1 therapy ;Completed surgical resection ;At the same time, standard postoperative treatment was performed 8 \~ 12 weeks of therapy;
- Must provide all exons of tumor tissue sequencing data, transcriptome sequencing data and the peripheral blood of all exons sequencing data;
- Completion of imaging records 1 week before personalized immunotherapy, including but not limited to full-body PET-CT and brain MRI,
- Haematological index： White blood cells ≥ 3500 / MCL; Lymphocytes \> 800/ MCL; neutrophils \> 1500/ MCL; Platelets \> 100000 / MCL; Hemoglobin \>10.0g/dL; Total serum bilirubin \<1.5× upper limit of normal value (ULN); AST/ALT\<2.0 times the upper limit of normal; Serum creatinine \<1.5 times the upper limit of normal；
- Pregnant, lactating women and women of child-bearing age must have a negative pregnancy test within 7 days before entering the group, and short-term have no fertility plan, and are willing to take protective measures (contraception or other birth control methods) before and during the clinical trial;
- Male patients are willing to take appropriate methods of contraception;
- Good compliance, able to follow research protocols and follow-up procedures;
Exclusion
- Diagnosed as other malignant tumor;
- No neoantigen was found in the sequencing data;
- Patients are unable to tolerate surgery and adjuvant therapy or patients with poor immune system status;
- There have been bone marrow or stem cell transplants;
- Received other systemic antitumor agents or systemic glucocorticoids with immunosuppressants;
- Received other vaccine inoculation 4 weeks before treatment;
- With HIV, HCV, HBV infection, severe asthma, autoimmune disease,immunodeficiency or treated with immunosuppressive drugs;
- Uncontrolled complications include, but are not limited to, active infection, symptomatic congestive heart failure, unstable angina pectoris, and arrhythmias;
- Infected with herpes virus (except those with scabs of more than 4 weeks);
- Infected with respiratory virus (except those who have recovered for more than 4 weeks);
- Have severe coronary or cerebrovascular disease, or other conditions considered ineligible by the investigator;
- Drug abuse. Clinical, psychological or social factor result in affecting informed consent or research implementation;
- Have a history of drug or vaccine allergies, or people who are allergic to other potential immunotherapies;
Key Trial Info
Start Date :
December 2 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2026
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT05307835
Start Date
December 2 2021
End Date
December 31 2026
Last Update
December 2 2025
Active Locations (1)
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1
The Second Affiliated Hospital of Zhejiang University
Hangzhou, Zhejiang, China, 310000