Status:
UNKNOWN
Clinical Study of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Premature Ovarian Insufficiency
Lead Sponsor:
Li-jun Ding
Conditions:
Premature Ovarian Insufficiency
Eligibility:
FEMALE
20-39 years
Phase:
NA
Brief Summary
This study was a single-center, randomized, controlled prospective study. Those who had premature ovarian failure and who had fertility requirements were enrolled in the study. To determine the effica...
Detailed Description
According to the enrollment and exclusion criteria, the patients were enrolled, and the subjects were randomly divided into two groups by computer randomization. Group A was hormone replacement combin...
Eligibility Criteria
Inclusion
- Those who meet the POF diagnostic criteria and have no spontaneous follicular activity;
- Married, 20 years old ≤ age \< 40 years old;
- The average diameter of each ovary is \> 10 mm;
- Have agreed to sign the informed consent form.
Exclusion
- Female and/or male chromosomal abnormalities;
- Endometriosis, adenomyosis;
- Postoperative ovarian borderline or malignant tumor;
- Uterine dysplasia;
- Associated with female autoimmune disease or other serious internal surgical diseases;
- hormone replacement contraindications;
- In the past 1 year, had received an experimental study of premature ovarian failure in the external hospital;
- Male azoospermia or severe oligozoospermia.
Key Trial Info
Start Date :
November 20 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2023
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT05308342
Start Date
November 20 2019
End Date
December 1 2023
Last Update
April 4 2022
Active Locations (1)
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1
Reproductive Medicine Center, The affiliated Drum Towel Hospital of Nanjing University Medical School
Nanjing, Jiangsu, China, 210008