Status:
COMPLETED
Analysis and Suppression of Tremor During Grasp Using Ultrasound Imaging and Electrical Stimulation
Lead Sponsor:
North Carolina State University
Collaborating Sponsors:
University of North Carolina, Chapel Hill
Conditions:
Parkinson Disease
Essential Tremor
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
Individuals experiencing tremors face difficulty performing activities of daily living caused by involuntary oscillation of the muscles in the hands and arms. Current solutions to help suppress tremor...
Eligibility Criteria
Inclusion
- Inclusion Criteria (Tremor Group):
- At least 40 years of age, and no more than 90 years of age.
- Meet UK Parkinson's disease brain bank diagnostic criteria
- Have clinical evidence of rest tremor of one or both upper extremities defined as involuntary, rhythmic oscillations about any joint within the upper extremities
- Tremor amplitude must be at minimum 1 cm as determined by expert opinion by a movement disorders specialist.
- Due to the nature of measurements occurring during a grasp maneuver, the tremor must be deemed to become re-emergent with a fixed posture. This shall be defined by development of postural tremor that does not begin immediately upon grasping the vertical object, but instead with a delay in development of oscillatory movement of at least half a second as timed by a stopwatch, and that may grow in amplitude over seconds to maximum amplitude without changing the force of the grasp at first. Note that within-individual intermittency and variability of tremor can be influenced by anxiety, stress, cold temperature, and fatigue. In an effort to reduce this variability, we will have subjects perform tasks in a comfortable area, providing up to 20 minutes to allow them to relax in a temperature-neutral location, and reduce anxiety
- Exclusion Criteria (Tremor Group):
- Muscle weakness as determined by Medical Research Council grade less than 5/5 on direct testing in the upper limb afflicted with rest tremor
- Infection at the upper limb at time of assessment
- Pre-existing, concomitant neuromuscular or cerebellar disorders
- Use of medications that can alter the function of the neuromuscular junction.
- Those with concomitant essential tremor as determined by history or confirmed by movement disorders specialist prior to assessments.
- Inclusion Criteria (Able Body):
- Subjects will fall under the able body category if they exhibit no movement disorders and can perform grasping motion with no inhibition.
Exclusion
Key Trial Info
Start Date :
April 11 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2025
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT05308368
Start Date
April 11 2021
End Date
July 31 2025
Last Update
October 27 2025
Active Locations (1)
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1
Engineering Building III
Raleigh, North Carolina, United States, 27606