Status:
RECRUITING
REperfusion Therapy for Acute Ischemic STrOke Due to Large aRtEry Occlusion
Lead Sponsor:
Beijing Tiantan Hospital
Collaborating Sponsors:
National Natural Science Foundation of China
Beijing Municipal Science & Technology Commission
Conditions:
Stroke
Vascular Occlusion
Eligibility:
All Genders
18+ years
Brief Summary
The aim of the study was to establish a clinical and advanced imaging database of acute ischemic stroke patients treated with mechanical thrombectomy due to large vessel occlusion of anterior circulat...
Detailed Description
The time-window of mechanical thrombectomy for ischemic stroke has extended from 4.5 hours to 24 hours based on the results of the DAWN and DEFUSE 3 trials. However, evidence on the effectiveness and ...
Eligibility Criteria
Inclusion
- Older than 18 years;
- Perfusion imaging completed including CTA+CTP or MRA+PWI+DWI before thrombectomy
- Large vessel occlusion of cerebral anterior circulation (ICA, MCA-M1 or MCA-M2) confirmed by CTA or MRA, planned to receive or received stenting or aspiration thrombectomy
- Time intervals ≤ 24 hours from stroke onset to groin puncture.(fulfilled the inclusion of DAWN or DEFUSE 3 trial if the time intervals from stroke onset to groin puncture was ≥6 hours)
- mRS score ≤2 before admission
- Informed consent obtained for longitudinal enrolled patients, waived of consent for retrospectively included cases
Exclusion
- Had a history of infective disease, immunity disease, radiotherapy at head or neck, carotid dissection or other carotid disease.
- Unable to receive CT or MR scan due to heart failure, cardiac pacemaker, metal implants or claustrophobia, etc.
- Unable to be injected with contrast agent due to allergy, renal dysfunction, etc.
- Unlikely to adhere to the study protocol or follow-up ( life expectancy ≤ 3 months)
- Already participated in other drug trials
Key Trial Info
Start Date :
February 23 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
1600 Patients enrolled
Trial Details
Trial ID
NCT05311605
Start Date
February 23 2023
End Date
December 31 2024
Last Update
March 21 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Yunyun Xiong
Beijing, China