Status:
COMPLETED
Examining Sex-based Differences in Metabolic and Mechanistic Responses to Disuse Induced Muscle Atrophy
Lead Sponsor:
McGill University
Conditions:
Muscle Atrophy
Muscle Disuse Atrophy
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
The purpose of the proposed research is to define whether there are differences between females and males (i.e. sex-based differences) in the metabolic and mechanistic regulation of disuse-induced mus...
Detailed Description
Patients in rehabilitation may undergo periods of prolonged limb immobilization in response to injury, surgery, or illness. Due to disuse, the size and strength of muscles controlling the affected lim...
Eligibility Criteria
Inclusion
- Aged between 18-35 years inclusive
- Healthy, recreationally active (active for \>5 hours/ week)
- Having given informed consent
Exclusion
- Type I or Type II diabetes
- Highly trained (active for \> 15 hours/week)
- Lower limb and/or back injuries in the last 6 months
- A history of thrombosis / cardiovascular disease
- Use of anticoagulants
- Musculoskeletal / orthopedic disorders
- Use of tobacco products
- Using medications known to modulate skeletal muscle metabolism including corticosteroids, hormone replacement therapy (HRT), non-steroidal anti-inflammatory drugs (i.e. paracetamol) and over-the-counter supplements including protein powder, creatine monohydrate, and fish oil
- Pregnant
- Currently participating in another clinical trial/ physical intervention research study
Key Trial Info
Start Date :
November 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 15 2024
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT05314413
Start Date
November 1 2022
End Date
November 15 2024
Last Update
November 25 2024
Active Locations (1)
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1
Currie Gynasium 309 - McGill University
Montreal, Quebec, Canada, H2W 1S4