Status:
RECRUITING
Cough Audio Classification as a TB Triage Test
Lead Sponsor:
University of Stellenbosch
Collaborating Sponsors:
Amsterdam Institute for Global Health and Development
University of Göttingen
Conditions:
Tuberculosis
Eligibility:
All Genders
12+ years
Brief Summary
TB is the single biggest infectious cause of death (1.5 million died in 2018), killing more HIV-positive people than any other disease, and is arguably the most important poverty-related disease in th...
Detailed Description
CAGE-TB is a diagnostic evaluation study that assesses a TB cough audio signature's potential to be used in a smartphone application to detect potential TB from a cough sound to screen (triage) TB. Th...
Eligibility Criteria
Inclusion
- participant must be at least 12 years old
- participant must have a prolonged cough (for at least two weeks)
- participant must provide informed consent
- participant shall have a known HIV status or be willing to undergo standard of care HIV testing and counseling
Exclusion
- individuals who refuse informed consent
- individuals who have received treatment for TB in the 60 days prior to enrolment
- individuals who are unable to provide a sputum specimen for microbiological testing
- individuals who have haemoptysis or a bloody cough with any forced coughs for audio recordings
Key Trial Info
Start Date :
April 19 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2027
Estimated Enrollment :
1751 Patients enrolled
Trial Details
Trial ID
NCT05317247
Start Date
April 19 2022
End Date
December 30 2027
Last Update
August 29 2025
Active Locations (2)
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1
Stellenbosch University
Cape Town, Western Cape, South Africa, 7505
2
Makerere University
Kampala, Kampala, Uganda, 7062