Status:
COMPLETED
Effect of Dietary Protein on the Regulation of Exosome microRNA Expression in Patients With Insulin Resistance.
Lead Sponsor:
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Conditions:
Insulin Resistance
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
miRNAs are small non-coding RNAs of approximately 22 nucleotides in length, which have the function of regulating gene expression at the post-transcriptional level through base complementation of prot...
Detailed Description
The study will evaluate the effect of 2 dietary interventions on the regulation of plasma exosome microRNA expression in patients with insulin resistance. STUDY PROGRAM The study will consist of 3 v...
Eligibility Criteria
Inclusion
- Adults (men and women) between the ages of 18 and 60.
- Patients with obesity (BMI ≥ 30 and ≤ 50 kg / m2) and with insulin resistance (HOMA - Insulin Resistance Index ≥ 2.5).
- Signature of letter of consent
Exclusion
- Patients with any type of diabetes.
- Patients with kidney disease diagnosed by a medical or with creatinine\> 1.3 mg / dL for men and \> 1.1 mg / dL for women and / or blood urea nitrogen \> 20 mg / dL.
- Patients with acquired diseases that produce obesity and diabetes secondarily.
- Patients who have suffered a cardiovascular event.
- Patients with weight loss \> 3 kg in the last 3 months.
- Patients with any catabolic diseases.
- Gravidity status
- Positive smoking and alcoholism
- Treatment with any medication
Key Trial Info
Start Date :
September 15 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 10 2024
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05318898
Start Date
September 15 2023
End Date
September 10 2024
Last Update
January 27 2025
Active Locations (2)
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1
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Mexico City, Mexico City, Mexico, 14080
2
Martha Guevara Cruz
Mexico City, Mexico, 14060