Status:
COMPLETED
Effects of Ketamine on Mentalizing and Metacognition in Healthy Volunteers
Lead Sponsor:
University Hospital, Bonn
Conditions:
Ketamine-Induced Psychotic Disorder
Social Cognition
Eligibility:
All Genders
18-35 years
Phase:
PHASE4
Brief Summary
Antipsychotic medication shows generally good effect sizes when looking at reduction of positive psychotic symptoms of schizophrenia, such as paranoia or delusion. However, social functioning often re...
Eligibility Criteria
Inclusion
- Potential participants are excluded based on the following criteria:
- history of psychiatric/neurological disorder (self and first-degree relatives)
- learning disabilities, or loss of consciousness for more than 5 minutes
- history of alcohol or drug abuse within the last 12 months
- history of ketamine abuse
- history of complications during anesthesia (self and first-degree relatives)
- serious physical illness
- claustrophobia
- color-blindness
- metalliferous implant
- visual impairments other than corrective lenses
- injury or disease of the inner ear with loss of hearing
- consumption of any prescription or over-the-counter medication 3 days previous to the examination
- pregnancy
- currently breastfeeding a baby
- hypotension (blood pressure \< 100/60)
- hypertension (blood pressure \> 140/90)
- underweight (BMI \<17)
- overweight (BMI ≥30)
- Recruited participants are required to meet the following criteria:
- height between 150 and 195 cm
- bodyweight between 50 and 99kg
- male or female
- right-handed
- physically, neurologically and psychiatrically healthy
- non-smoker
- normal or corrected-to-normal eye-sight
- good command of German language
Exclusion
Key Trial Info
Start Date :
June 15 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 27 2020
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT05320991
Start Date
June 15 2019
End Date
September 27 2020
Last Update
April 18 2022
Active Locations (1)
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1
Department of Psychiatry and Psychotherapy, University Hospital Bonn
Bonn, Germany, 53127