Status:
RECRUITING
Wrist Extensor MEP Up-conditioning for Individuals With Incomplete Spinal Cord Injury
Lead Sponsor:
Medical University of South Carolina
Conditions:
Spinal Cord Injuries
Quadriplegia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to examine the relationship between common clinical assessments and measurements of the function of brain-spinal cord-muscle connections, and to examine the effects of tra...
Eligibility Criteria
Inclusion
- a history of injury to spinal cord at or above C6
- neurologically stable (\>6 mo post SCI)
- medical clearance to participate
- weak wrist extension at least unilaterally
- expectation that current medication will be maintained without change for at least 3 months. Stable use of anti-spasticity medication (e.g., baclofen, diazepam, tizanidine) is accepted. In participants with bilateral wrist extension weakness, the more severely impaired arm is studied.
Exclusion
- motoneuron injury
- medically unstable condition
- cognitive impairment
- a history of epileptic seizures
- metal implants in the cranium
- implanted biomedical device in or above the chest (e.g., a cardiac pacemaker, cochlear implant)
- no measurable MEP elicited in the ECR
- unable to produce any voluntary ECR EMG activity
- extensive use of functional electrical stimulation to the arm on a daily basis
- pregnancy (due to changes in posture and potential medical instability).
Key Trial Info
Start Date :
October 12 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT05321017
Start Date
October 12 2021
End Date
June 30 2026
Last Update
June 19 2025
Active Locations (1)
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1
Medical University of South Carolina
Charleston, South Carolina, United States, 29425