Status:
COMPLETED
Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial
Lead Sponsor:
Washington University School of Medicine
Conditions:
Abortion, Second Trimester
PPROM
Eligibility:
FEMALE
18+ years
Phase:
PHASE4
Brief Summary
When time allows, administration of mifepristone prior to second trimester induction of labor decreases total labor time. However, in the setting of many pregnancy complications, decreasing time from ...
Detailed Description
Up to 3% of pregnancies in the second trimester are nonviable and require delivery due to myriad complications including stillbirth, preterm prelabor rupture of membranes (PPROM) at a previable gestat...
Eligibility Criteria
Inclusion
- 18 years or older
- 14 and 28 weeks' gestation
- Singleton gestation
- Nonviable fetus (i.e. fetal demise or previable gestational age/weight or lethal fetal anomaly)
- Requires induction of labor
- If fetal cardiac motion, abortion being performed for medical emergency per MO laws and consents completed
Exclusion
- Contraindication to mifepristone
- Plan for surgical evacuation of uterus
- Contraindication to vaginal delivery
- Plan to initiate induction with any medication or device except misoprostol
- Declines participation
Key Trial Info
Start Date :
July 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 14 2025
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05322252
Start Date
July 1 2022
End Date
July 14 2025
Last Update
July 17 2025
Active Locations (1)
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1
Barnes-Jewish Hospital
St Louis, Missouri, United States, 63110