Status:
UNKNOWN
Nectin-4 Targeting ADC Probe for PET Imaging in Solid Tumors
Lead Sponsor:
Peking University Cancer Hospital & Institute
Conditions:
Solid Tumor
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
To study the normal physiological distribution of the probe 124I-EV in human body and its ability to detect overexpression of Nectin-4 in tumor lesions.
Detailed Description
Nectin-4 is highly expressed in different types of cancer and is involved in various aspects of tumor proliferation, angiogenesis, metastasis, tumor recurrence, and DNA repair. Therefore, the developm...
Eligibility Criteria
Inclusion
- 18-75 years old, male or female;
- Patients recommended by clinicians to undergo PET/CT examination for tumor diagnostic staging;
- The subject patients could fully understand and voluntarily participate in the experiment, and signed the informed consent.
- Normal heart function;
- Good follow-up compliance;
- presence of at least one measurable target lesion according to RECIST1.1 criteria
- Women of childbearing age (15-49 years) must have a negative pregnancy test within 7 days before the start of the test; Fertile men and women must agree to use effective contraception to prevent pregnancy during the study period and for 3 months after the test.
Exclusion
- Serious abnormality of liver, kidney and blood;
- Pregnant patients;
- Pregnant and lactation women;
- 3\) unable to lie flat for half an hour; 4) Refuse to join the clinical investigator; 5) Suffering from claustrophobia or other mental diseases; 6) Other conditions that researchers deem unsuitable for participating in the experiment.
Key Trial Info
Start Date :
May 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT05322512
Start Date
May 1 2024
End Date
December 1 2025
Last Update
November 29 2023
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