Status:
UNKNOWN
Molecular, Metabolomic and Nutritional Changes After Metabolic Surgery
Lead Sponsor:
Ministry of Health, Malaysia
Collaborating Sponsors:
Universiti Putra Malaysia
Conditions:
Obesity; Endocrine
Diabete Type 2
Eligibility:
All Genders
18-65 years
Brief Summary
Obesity is a major risk factor for Type 2 Diabetes (T2D) and cardiovascular diseases, such as hypertension and dyslipidemia. Recently, weight loss surgery (i.e., metabolic or bariatric surgery) has be...
Detailed Description
Study design This is a prospective single centre study to explore molecular aspects and metabolomic changes among 102 obese individuals of different diabetes status, undergoing metabolic surgery, whi...
Eligibility Criteria
Inclusion
- Patients' Inclusion Criteria
- BMI \> 30kg/m2
- Men and women
- Ages 18-65 years old
- Diabetes status (non diabetic, pre diabetes and diabetes)
- Patients who will undergo metabolic surgery
- Healthy individuals' Inclusion Criteria
- BMI \< 30kg/m2,
- Men and women
- Ages 18-65 years old
- No diabetes
- No pre diabetes
- No other co-morbidities (high total cholesterol, high triglycerides, high blood pressure)
Exclusion
- Patients' Exclusion Criteria
- BMI \<30 kg/m2
- Use of medications that may affect body weight at screening or during a 3 month period prior
- Other medical conditions like Cushing's, acromegaly, Heart failure, Crohn's disease, etc
- Alcohol dependence
- Healthy Individuals' Exclusion Criteria
- BMI \> 30 kg/m2 (obese)
- BMI \< 18.5 kg/m2 (underweight)
- Diabetes status (pre diabetes and diabetes)
- Use of medications that may affect body weight at screening or during a 3 month period prior
- Other co-morbidities (high total cholesterol, high triglycerides, high blood pressure, cancer)
- Other medical conditions like Cushing's, acromegaly, Heart failure, Crohn's disease, etc
- Alcohol dependence
Key Trial Info
Start Date :
June 24 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2024
Estimated Enrollment :
102 Patients enrolled
Trial Details
Trial ID
NCT05322551
Start Date
June 24 2022
End Date
December 1 2024
Last Update
September 1 2022
Active Locations (1)
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1
Institute for Medical Research, National Institutes of Health
Shah Alam, Selangor, Malaysia, 40170