Status:
RECRUITING
Tracking of Upper Limb Sensory and Motor Recovery in Asian Stroke Survivors
Lead Sponsor:
Tan Tock Seng Hospital
Collaborating Sponsors:
Rehabilitation Research Institute of Singapore (RRIS)
Singapore-ETH Centre (SEC)
Conditions:
Stroke
Eligibility:
All Genders
21-90 years
Brief Summary
As Singapore's population is aging rapidly, the incidence rate of stroke has been increasing in the past years. Rehabilitation is essential for the resumption of daily activities, and with the appropr...
Detailed Description
Stroke is a leading contributor to disability in Singapore, partially driven by a reduced ability to use the upper limb in their daily lives. Reduced upper limb use commonly results from a variety of ...
Eligibility Criteria
Inclusion
- Stroke confirmed by neurologists, neurosurgeons and brain imaging (CT, CT angiogram, MRI, MR angiogram)
- First ever confirmed stroke
- Asian ethnicity
- Age 21-90 years
- Montreal Cognitive Assessment (MOCA) scores 21/30 and above
- Admission to rehabilitation ward is within 8 weeks of stroke onset
Exclusion
- Recurrent stroke or transient ischaemic attack (TIA)
- Upper limb impairment not related to stroke: e.g., subarachnoid haemorrhage, traumatic brain injury or brain tumours
- Bilateral upper limb impairment.
- Uncontrolled medical conditions such as hypertension, hypotension, diabetes mellitus, unstable angina, cardiac failure or sepsis will be excluded.
- Active fractures or arthritis of upper limb joints/bones
- Visual Analogue Scale (VAS) pain \> 5/10
- MOCA \< 21/30
- Severe behavioural disturbance or agitation or epilepsy or untreated depression
- Life expectancy \< 6 months
- End organ failures on replacements (renal dialysis or renal replacement therapies)
- Minimally responsive or unresponsive awareness (vegetative) states
- Pregnancy or lactation states
- Admission to rehab ward later than 8 weeks post-stroke
- (For TMS assessments only) History of epilepsy or seizures, or cranial surgeries, or have metal implants in body or head, or have implanted electronics, or have metallic valve, or skull fracture or brain injury, or head or brain surgeries.
Key Trial Info
Start Date :
April 26 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2026
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT05322837
Start Date
April 26 2023
End Date
January 1 2026
Last Update
April 15 2025
Active Locations (1)
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1
Tan Tock Seng Hospital
Singapore, Singapore