Status:
UNKNOWN
High-definition Transcranial Direct Current Stimulation (HD-tDCS) in Late-life Depression (LLD)
Lead Sponsor:
The University of Hong Kong
Conditions:
Depression in Old Age
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
To determine the efficacy of a 2-week daily programme (10 sessions) of HD-tDCS to augment antidepressant therapy in subjects with late-life depression who had residual depressive symptoms despite adeq...
Detailed Description
Background: Hong Kong is facing a significant challenge in ageing population. A significant proportion of older adults suffered from depression. As the local population is ageing rapidly, the burden ...
Eligibility Criteria
Inclusion
- 60 years of age or above
- Right-handedness, as determined by the Edinburgh Handedness Inventory (to homogenise neuroanatomical targeting)
- Chinese ethnicity
- Fulfil the criteria of Major Depressive Disorder (single or recurrent episode) and in partial remission, defined by the 5th Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5)
- Presence of mild to severe level of depressive symptoms measured and defined by HAM-D-17 score ≥8 and ≤ 52\[22\]
- Suboptimal treatment response with at least one adequate antidepressant trial defined as full or best tolerated doses at least 6 weeks
- Stable dosage of antidepressants or other treatments for depression in recent 4 weeks
- Valid informed written consent
Exclusion
- A DSM-5 diagnosis other than Depressive Disorders (e.g., bipolar and related disorders, schizophrenia spectrum and other psychotic disorders).
- A Hong Kong Chinese version of the Montreal Cognitive Assessment (HK-MoCA) score below the second percentile according to the subject's age and education level (to exclude subjects with existing dementia)
- Alcohol or substance dependence
- Active suicidal ideation or a suicide attempt within the past month
- Concomitant unstable medical condition or major neurological conditions
- Significant communication impairment
Key Trial Info
Start Date :
February 22 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 22 2024
Estimated Enrollment :
58 Patients enrolled
Trial Details
Trial ID
NCT05322863
Start Date
February 22 2021
End Date
February 22 2024
Last Update
April 12 2022
Active Locations (1)
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1
Department of Psychiatry, University of Hong Kong
Hong Kong, Hong Kong