Status:
COMPLETED
Microvascular Function in Patients Undergoing Transcatheter Aortic Valve Implant (TAVI) for Severe Symptomatic Aortic Stenosis: Association With Myocardial Fibrosis
Lead Sponsor:
Matteo Montorfano
Conditions:
Severe Symptomatic Aortic Stenosis
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Microvascular function in patients undergoing Transcatheter Aortic Valve Implant (TAVI) for severe symptomatic aortic stenosis: association with myocardial fibrosis
Detailed Description
Severe symptomatic aortic stenosis is commonly encountered in clinical practice, affecting close to 5% of individuals older than 65 years of age, and carries a dismal prognosis if left untreated.(1,2)...
Eligibility Criteria
Inclusion
- • All patients referred to IRCCS Ospedale San Raffaele who are candidates to receive a TAVI implant for severe, symptomatic aortic stenosis under current appropriateness criteria and clinical practice guidelines will be considered eligible to take part in the study
Exclusion
- Age \<18 years
- Inability to express informed consent to take part in the present study.
- Pregnancy or lactation
- Pre-existing known disease determining a prognosis quo ad vitam shorter than the follow up of the present study
- Significant chronic kidney disease (estimated glomerular filtration rate \<30 ml/min)
- Known significant epicardial coronary artery stenosis
- Known contraindication to adenosine administration:
- Known allergic reactions
- Second or third degree atrioventricular block before the procedure (in absence of a functional permanent pacemaker)
- Long QT syndrome
- Unstable angina
- Severe hypotension
- Acutely decompensated heart failure
- Chronic obstructive pulmonary disease with bronchospasm
- Concomitant use of dypiridamole
Key Trial Info
Start Date :
July 8 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 10 2025
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT05326126
Start Date
July 8 2021
End Date
September 10 2025
Last Update
September 16 2025
Active Locations (1)
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1
IRCCS San Raffaele
Milan, Italy, Italy, 20132