Status:
RECRUITING
Zanubrutinib in Patients With Waldenström's Macroglobulinemia, Chronic Lymphocytic Leukemia, Marginal Zone Lymphoma and Follicular Lymphoma
Lead Sponsor:
iOMEDICO AG
Collaborating Sponsors:
BeOne Medicines I GmbH Switzerland
Conditions:
Waldenström's Macroglobulinemia
Chronic Lymphocytic Leukemia
Eligibility:
All Genders
18+ years
Brief Summary
The objective of this NIS is to evaluate medical resource utilization, where data is rare in all cohorts, patient's QoL and effectiveness of zanubrutinib treatment in adult patients with WM, CLL, MZL ...
Detailed Description
ARIADNE will collect and analyze data of adult patients with WM, CLL, MZL or FL in need of treatment. The study will explore the medical resource utilization during therapy with zanubrutinib (Brukinsa...
Eligibility Criteria
Inclusion
- Waldenström's macroglobulinemia (all treatment lines) OR
- Chronic lymphocytic leukemia (all treatment lines) OR
- Marginal zone lymphoma (≥2 treatment line and at least one anti-CD20 antibody-based previous therapy)
- Follicular lymphoma (≥3 treatment line)
- Signed and dated informed consent form
- Treatment with zanubrutinib according to current SmPC for WM, CLL and MZL
- Treatment with zanubrutinib + obinutuzumab for FL according to current SmPC
- Treatment decision before inclusion into this non-interventional study
- Age ≥18 years.
Exclusion
- Contraindications according to SmPC for patients with WM, CLL, MZL or FL
- Participation in an interventional clinical trial during zanubrutinib treatment.
Key Trial Info
Start Date :
April 26 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2028
Estimated Enrollment :
705 Patients enrolled
Trial Details
Trial ID
NCT05326308
Start Date
April 26 2022
End Date
August 1 2028
Last Update
September 23 2025
Active Locations (2)
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1
Universitätsklinikum Salzburg, Klinik für Innere Medizin III
Salzburg, Austria, A-5020
2
Lübecker Onkologische Schwerpunktpraxis
Lübeck, Schleswig-Holstein, Germany, D-23562