Status:
COMPLETED
Study on the Association Between Vitamin C Deficiency and Diarrhea in Children
Lead Sponsor:
Institut Pasteur
Collaborating Sponsors:
Institut Cochin
University of Copenhagen
Conditions:
Diarrhea
Infantile
Eligibility:
All Genders
2-5 years
Brief Summary
Diarrheal disease is the second leading cause of death in children under five, althought it is both preventable and treatable. The causative factors of diarrheal diseases vary a lot from region to reg...
Detailed Description
Diarrheal disease is the second leading cause of death in children under five, althought it is both preventable and treatable. The causative factors of diarrheal diseases vary a lot from region to reg...
Eligibility Criteria
Inclusion
- Controls :
- Inclusion Criteria:
- not suffering of diarrhea
- no fever
- no sign of infection
- Exclusion criteria :
- Suspected or diagnosed infectious diseases
- Known genetic diseases
- Known diseases that may interfere with iron and/or vitamin C metabolism
- Known inflammatory diseases
- Malnutrition
- Diarrhea
- Fever
- Positive malaria rapid diagnostic test (Africa)
- Chronic diarrhea cases :
- Inclusion Criteria:
- Children suffering from chronic diarrhea defined by the emission of at least 3 soft or liquid stools per day for at least 4 weeks.
- Exclusion criteria :
- Suspected or diagnosed infectious diseases
- Known genetic diseases
- Known diseases that may interfere with iron and/or vitamin C metabolism
- Known inflammatory diseases
- Positive malaria rapid diagnostic test (Africa)
- Antibiotic treatment prescribed within 10 days prior to sampling
- Nutritional supplements in the three months prior to sampling
- Vitamin C supplementation in the last 3 months prior to blood collection
- Acute diarrhea cases :
- Inclusion Criteria:
- Children suffering from acute diarrhea defined as 3 or more loose or watery stools per day for at least 3 consecutive days and up to 10 consecutive days.
- Exclusion criteria :
- Malnutrition
- Suspected or diagnosed infectious diseases
- Known genetic diseases
- Known diseases that may interfere with iron and/or vitamin C metabolism
- Known inflammatory diseases
- Positive malaria rapid diagnostic test (Africa)
- Antibiotic treatment prescribed within 10 days prior to sampling
- Nutritional supplements in the three months prior to sampling
- Vitamin C supplementation in the last 3 months prior to blood collection
Exclusion
Key Trial Info
Start Date :
April 25 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 31 2024
Estimated Enrollment :
288 Patients enrolled
Trial Details
Trial ID
NCT05328037
Start Date
April 25 2022
End Date
March 31 2024
Last Update
May 1 2024
Active Locations (3)
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1
Complexe Pédiatrique
Bangui, Central African Republic
2
Hopital Necker
Paris, France, 75015
3
Centre Hospitalier Territorial Gaston Bourret
Noumea, New Caledonia