Status:
UNKNOWN
Volume Mode Non-invasive Ventilation in Amyotrophic Lateral Sclerosis
Lead Sponsor:
University Hospitals Coventry and Warwickshire NHS Trust
Conditions:
Amyotrophic Lateral Sclerosis
Respiratory Failure
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
The purpose of this study is to assess the efficacy of using intelligent volume assured pressure support (iVAPS-AE) versus spontaneous timed (ST) modes of non-invasive ventilation (NIV) in patients di...
Detailed Description
Amyotrophic lateral sclerosis (ALS) is one of five motor neurone diseases (MNDs). It is a rare, incurable disease characterised by progressive destruction of nerve cells called motor neurones that ins...
Eligibility Criteria
Inclusion
- Patients with respiratory failure secondary to ALS (diagnosed either at an MND MDT or specialist neurology clinic) according to criteria set out in the NICE guideline (NG42) (2016); Motor neurone disease: assessment and management.
- Patients able to provide informed consent to take part in the research study.
- Patients not contraindicated to commence NIV in accordance with local protocol.
- Patients not currently enrolled in another research study that could alter disease progression.
Exclusion
- Acutely unwell or medically complicated patients as assessed by lead investigator. These patients will be urgently reviewed by a dedicated Consultant Physician. The Principal Investigator will be immediately informed.
- An inability to provide informed consent.
- An inability to use NIV.
- Patients whom are contraindicated to commence NIV in accordance with local protocol.
Key Trial Info
Start Date :
March 15 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 15 2024
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05328492
Start Date
March 15 2022
End Date
March 15 2024
Last Update
June 1 2023
Active Locations (1)
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1
University Hospital Coventry and Warwickshire NHS Trust
Coventry, West Midlands, United Kingdom, CV2 2DX