Status:
COMPLETED
Pathophysiological Mechanisms of Trigeminal Neuralgia - Neurophysiological Assessment of the Blink-reflex
Lead Sponsor:
Danish Headache Center
Conditions:
Trigeminal Neuralgia
Eligibility:
All Genders
18+ years
Brief Summary
This study aims to increase the understanding of the pathophysiology of trigeminal neuralgia by investigating the potential association between blink reflex abnormalities and phenotypical traits e.g. ...
Detailed Description
We hypothesize: Patients with classical trigeminal neuralgia have a prolonged latency and reduced amplitudes of the blink-reflex on the pain side compared to patients with idiopathic TN The latency ...
Eligibility Criteria
Inclusion
- Subjects of both sexes with trigeminal neuralgia must meet the following inclusion criteria to be eligible for participation:
- Age 18 years or older
- Must be able to give Signed Informed Consent prior to study entry. Appendix X
- Must fulfill the ICHD-3 diagnostic criteria1 for classical, idiopathic or secondary TN.
- Has had a 3.0 Tesla MRI according to the trigeminal neuralgia protocol, maximum 2 years before or after the assessment of the blink-reflex.
- Has had a semi-structured interview and neurological examination by the independent assessors, maximum 2 years before or after the assessment of the blink-reflex.
Exclusion
- Subjects will be excluded if one of the following exclusion criteria is met:
- If the patient is not able to give informed consent due to mental challenges
- Previous neurosurgical treatment (microvascular decompression and/or ablative procedures) for trigeminal neuralgia
- Bilateral trigeminal neuralgia
- Symptomatic trigeminal neuralgia
- Findings of sensory abnormalities detected at clinical neurological examination
Key Trial Info
Start Date :
May 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2022
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05328661
Start Date
May 1 2021
End Date
December 1 2022
Last Update
January 30 2025
Active Locations (1)
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1
Danish Headache Center
Glostrup Municipality, Denmark, 2600