Status:
COMPLETED
β-alanine Supplementation in Adults With Overweight/Obesity
Lead Sponsor:
Nottingham Trent University
Collaborating Sponsors:
Aston University
Conditions:
Prediabetes
Hyperglycemia
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The study will investigate the safety, feasibility, and efficacy of beta-alanine supplementation in adults with overweight or obesity. Beta-alanine is a widely used dietary supplement that can increas...
Detailed Description
Overweight and obesity are major public health problems. Recent estimates show that 64.3% of people in the UK are living with overweight or obesity; this is projected to increase to 71% by 2040, which...
Eligibility Criteria
Inclusion
- Males and females aged 18 to 75 years
- Body Mass Index (BMI) ≥25 to \<40 kg/m2
- Able to provide informed consent
Exclusion
- Weight loss or gain ≥5 kg in the prior 6 months
- Current participation in another clinical research trial
- Substance abuse, presence of an eating disorder or purging behaviour
- Known mental health illness requiring active treatment
- Known cognitive impairment
- Inability to understand conversational English
- Presence of type-1 or type-2 diabetes mellitus
- Use of carnosine or β-alanine supplements in the prior 6 months
- Current breastfeeding, pregnancy, or consideration of pregnancy
- Known comorbidities which may impact on study aims (e.g., cancer, heart failure, or chronic kidney disease) or measurement of study outcomes (e.g., sickle cell anaemia or previously known haemoglobinopathy)
- Use of weight loss or glucose lowering drugs (e.g., orlistat, thyroxine, metformin, insulin, glucagon-like-peptide-1 analogues), long-term corticosteroids, or other drugs which may impact on measurement of study outcomes
Key Trial Info
Start Date :
April 5 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 20 2023
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05329610
Start Date
April 5 2022
End Date
July 20 2023
Last Update
September 1 2023
Active Locations (2)
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1
Nottingham Trent University
Nottingham, Nottinghamshire, United Kingdom, NG11 8NS
2
Aston University
Birmingham, West Midlands, United Kingdom, B4 7ET