Status:
UNKNOWN
Collagenase Chemonucleolysis vs Percutaneous Endoscopic Lumbar Discectomy (PELD) for Lumbar Disc Herniation
Lead Sponsor:
Shenzhen People's Hospital
Conditions:
Lumbar Disc Herniation
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Lumbar disc herniation compressed the nerve cause pain, numbness, weak legs called sciatica, which seriously decrease the quality of life and work efficiency. Both collagenase chemonucleolysis(CCNL) a...
Detailed Description
Lumbar disc herniation (LDH) is a common disease with an incidence of 1%-3%, usually manifested as low back pain radiating to the lower extremities, which seriously affects patients' quality of life. ...
Eligibility Criteria
Inclusion
- at least six weeks of excessive radiating leg pain with no tendency for any clinical improvement despite conservative therapy
- have a nerve root compression by a lumbar disc herniation proven by magnetic resonance imaging
Exclusion
- previous surgery at the same or adjacent disc level;
- isthmic or degenerative spondylolisthesis
- pregnancy
- severe comorbid medical or psychiatric disorder (American Society of Anesthesiologists' classification \>2);
- severe caudal or cranial sequestration of disc fragments, defined as sequestration towards more than half of the adjacent vertebra;
- contraindication for surgery
Key Trial Info
Start Date :
January 15 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 28 2023
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT05330806
Start Date
January 15 2021
End Date
June 28 2023
Last Update
March 10 2023
Active Locations (1)
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1
ShenzhenPH
Shenzhen, Guangdong, China, 518000