Status:

TERMINATED

A Human Monoclonal Antibody Against Staphylococcus Aureus Alpha Toxin in Mechanically Ventilated Adult Subjects - 2

Lead Sponsor:

Aridis Pharmaceuticals, Inc.

Conditions:

Ventilator Associated Pneumonia

Staphylococcus Aureus

Eligibility:

All Genders

12-65 years

Phase:

PHASE3

Brief Summary

Clinical trial looking at safety and efficacy of suvratoxumab in prevention of pneumonia caused by Staphylococcus aureus in high-risk patients

Detailed Description

This is a Phase 3, randomized, double-blind, placebo-controlled study evaluating the efficacy of a single IV dose of suvratoxumab in mechanically ventilated subjects in the ICU who are at high risk fo...

Eligibility Criteria

Inclusion

  • Colonized with Staphylococcus aureus;
  • Expected to require prolonged intubation and mechanical ventilation, without any evidence of active pneumonia.

Exclusion

  • Staphylococcal disease at randomisation;
  • Lung injury score consistent with pneumonia;
  • Chronic tracheostomy patients;
  • The study subject is moribund
  • Receipt of anti- S. aureus systemic antibiotics
  • Active pulmonary disease

Key Trial Info

Start Date :

September 2 2022

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

July 8 2024

Estimated Enrollment :

24 Patients enrolled

Trial Details

Trial ID

NCT05331885

Start Date

September 2 2022

End Date

July 8 2024

Last Update

March 24 2025

Active Locations (27)

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Page 1 of 7 (27 locations)

1

Research Site Bel03

Haine-Saint-Paul, Belgium

2

Research Site Bel02

Ottignies, Belgium

3

Research Site Bel05

Yvoir, Belgium

4

Research Site Fra05

Argenteuil, France