Status:
RECRUITING
Sex Differences in Metabolism Following a High-fat Meal
Lead Sponsor:
Kirsten Bell
Collaborating Sponsors:
McMaster University
Conditions:
Healthy Nutrition
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
Long-term consumption (i.e., several weeks to months) of a diet that is high in fat (\>35% daily calories from fat) is associated with the development of insulin resistance, a condition that can lead ...
Detailed Description
Long-term high-fat feeding is known to induce insulin resistance and impair whole-body glucose clearance in humans, yet knowledge of the glucose metabolic effects of high-fat feeding remains incomplet...
Eligibility Criteria
Inclusion
- BMI between 18.5 and 30.0 kg/m2
- Weight stable for the past 6 months (± 2kg)
- Exercise at or below the Canadian Physical Activity Guidelinesa
- Fasting blood glucose \<6.0 mM
- Resting blood pressure \<140/90 mmHg
- No hormone-altering contraceptive use (e.g., pill, patch, ring, injection)
Exclusion
- Smoking
- Diabetes, cancer, or other metabolic disorders
- Cardiac or gastrointestinal problems
- Infectious disease
- Barium swallow or nuclear medicine scan in the previous 3 weeks
- Pregnant or breastfeeding
- Diagnosis of polycystic ovary syndrome
- Follow a vegan or vegetarian diet
- Not fully vaccinated against COVID19
Key Trial Info
Start Date :
October 4 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 30 2027
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT05332301
Start Date
October 4 2022
End Date
May 30 2027
Last Update
August 19 2025
Active Locations (1)
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1
McMaster University
Hamilton, Ontario, Canada, L8S 4K1