Status:
RECRUITING
Establishing a Prognostic Model for Stroke Recovery
Lead Sponsor:
National University Hospital, Singapore
Collaborating Sponsors:
Alexandra Hospital
National University of Singapore
Conditions:
Stroke, Acute
Eligibility:
All Genders
21-80 years
Phase:
NA
Brief Summary
This main aim of the study is to investigate the changes in neurophysiological features after stroke, and its association with upper limb motor recovery, so as to establish a prognostic model for uppe...
Detailed Description
This study comprises 2 parts. Study 1 is a longitudinal cohort study to characterize the neurophysiological changes with upper limb motor recovery in stroke patients with moderate to severe upper limb...
Eligibility Criteria
Inclusion
- Inclusion criteria for stroke patients:
- 21-80 years old;
- First ever stroke less than 6 weeks;
- Moderate to severe upper limb impairment with Manual Muscle Testing (MMT) score on shoulder abduction plus finger extension (SAFE) \<5 within the first week post-stroke.
- Inclusion criteria for healthy subjects:
- Age 21-80 years old;
- No known medical history.
- Exclusion criteria for stroke patients:
- Pregnancy;
- Any metal implants inside the body that are contraindications of MRI scan;
- cardiac pacemakers;
- History of epilepsy;
- Sensorimotor disturbance due to other causes other than stroke;
- Claustrophobia;
- Uncontrolled medical conditions including hypertension, diabetes mellitus and unstable angina;
- Major depression and a history of psychotic disorders;
- Terminal diagnosis with life expectancy \<=1 year.
- Exclusion criteria for healthy subjects:
- Pregnancy;
- Any metal implants inside the body that are contraindications of MRI scan;
- cardiac pacemakers;
- Claustrophobia.
Exclusion
Key Trial Info
Start Date :
September 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 16 2026
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT05332652
Start Date
September 1 2020
End Date
July 16 2026
Last Update
August 16 2024
Active Locations (2)
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1
Alexandra Hospital
Singapore, Singapore
2
National University Hospital
Singapore, Singapore