Status:
RECRUITING
Oxalate and Citrate
Lead Sponsor:
University of Chicago
Conditions:
Kidney Stone
Normal Controls
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
This is a single-center study that aims to earn more about how two different compounds found in food, oxalate and citrate, may affect a person's chances of forming kidney stones.
Detailed Description
Experimental Design and Implications Administration of oral oxalate without citrate will determine the contribution of diet to this association. We will measure fractional excretion of oxalate and cit...
Eligibility Criteria
Inclusion
- Stone formers:
- Age 18-70
- History of at least one calcium-based kidney stone
- Non-stone formers (controls):
- Age 18-70
- No history of kidney stone
- 24-hour urine oxalate within lab normal (\<50mg/day)
Exclusion
- History of primarily uric acid, cysteine, or struvite stones.
- History of severe acid-base abnormality, very low (less than 100mg/day) or very high (greater than 1500mg/day) urine citrate.
- Any controls or stone-forming participants who cannot stop diuretic medication or alkali supplementation for the course of the study period.
- Non-stone formers and stone-formers with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.
Key Trial Info
Start Date :
October 27 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT05334979
Start Date
October 27 2022
End Date
December 1 2026
Last Update
January 8 2026
Active Locations (1)
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1
University of Chicago Medical Center
Chicago, Illinois, United States, 60637