Status:
COMPLETED
Microchimerism in Patients With Recurrent Pregnancy Losses
Lead Sponsor:
Caroline Nørgaard-Pedersen
Collaborating Sponsors:
Department of Clinical Immunology, Odense University Hospital, DK
Aalborg University Hospital
Conditions:
Recurrent Pregnancy Loss, Not Pregnant
Eligibility:
All Genders
Phase:
NA
Brief Summary
This pilot study aims to evaluate if microchimeric cells in a patient with recurrent pregnancy loss (RPL) can be detected by the blood analysis for the presence of the DYS14 gene and the use of indel-...
Detailed Description
To the investigators' knowledge, no previous study has determined the origin of microchimeric cells, and therefore, this pilot study will use a newly developed genetic analysis which will compare DNA ...
Eligibility Criteria
Inclusion
- sRPL patient (proband):
- ≥3 consecutive pregnancy losses ≤12 weeks of gestation, which do not include confirmed ectopic or molar pregnancies.
- Age \<41 years at time of admission
- Patients who have minimum one alive older brother with a common mother and prior birth of a boy, and patients who have minimum one alive older brother with a common mother and prior birth of a girl.
Exclusion
- Significant intrauterine malformations
- Thyroid dysfunction
- Known chromosomal abnormality
- An older brother, a son or a daughter from whom we cannot not collect a swab test e.g., due to lack of consent, death, distance etc.
- Transplant recipient
- Transfusion recipient
- Pregnancy at the time the blood sample is collected
- Older Brother:
- Inclusion Criteria:
- Age difference between proband and the older brother \<15 years
- Common mother with the proband
- sRPL patient's child:
- Inclusion Criteria:
- Age \<15 years
Key Trial Info
Start Date :
April 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 5 2024
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT05340556
Start Date
April 1 2022
End Date
February 5 2024
Last Update
November 24 2025
Active Locations (1)
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1
Aalborg University Hospital
Aalborg, Denmark, 9000