Status:
UNKNOWN
mGluR5 Imaging in ALS Using PET
Lead Sponsor:
Nathalie Braun
Collaborating Sponsors:
University of Zurich
ETH Zurich
Conditions:
Amyotrophic Lateral Sclerosis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In ALS models, it was shown that receptors, that bind an important messenger substance (glutamate) in the brain, are increased. In this research project, the investigators want to use a specific radio...
Detailed Description
With this study, the investigators want to examine whether receptors (docking points on the surface of a nerve cell) that bind an important messenger substance in the brain (glutamate) are increased i...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Clinically probable, probable laboratory supported, or definite ALS according to the revised version of the El Escorial World Federation of Neurology criteria (EEC) (45)
- Disease duration ≤18 months
- Pre-study ALSFRS-R progression between disease onset and screening of - 0.4 points/month or worse (calculated by ALSFRS -R total score decline form 48 divided by the months since onset of ALS symptoms)
- Upright slow vital capacity (sVC) ≥65 % of normal (best of three measurements)
- Exclusion Criteria :
- Previous participation in another clinical study involving trial medication within the preceding 12 weeks
- History or presence of significant psychiatric disease, such as depression, evaluated with the ALS depression questionnaire (ADI-12) ≥ 23 (43) since depression has an impact on mGluR5 expression (44)
- Use of tobacco, including cigarettes, smokeless tobacco, cigars, and pipes; Ex- smoker having quit smoking ≥ 2 years
Exclusion
Key Trial Info
Start Date :
April 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2025
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05340660
Start Date
April 1 2022
End Date
April 1 2025
Last Update
April 22 2022
Active Locations (1)
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1
Neuromuscular Center/ALS Clinic, Cantonal Hospital St. Gallen
Sankt Gallen, Switzerland, 9007