Status:
COMPLETED
Impact Loading Effect on Bone Biomarkers in Female Runners
Lead Sponsor:
Virginia Polytechnic Institute and State University
Conditions:
Relative Energy Deficiency in Sport
Eligibility:
FEMALE
18-35 years
Phase:
NA
Brief Summary
This study is a randomized, cross-over intervention study that will evaluate the effect of brief, high-impact loading exercises on biomarkers of bone metabolism in energy-restricted female runners. Vo...
Detailed Description
Many long-distance runners struggle to consume enough calories each day to match the number of calories they are burning during exercise and as part of daily living. Undereating for long periods of ti...
Eligibility Criteria
Inclusion
- Females runners with regular menstrual cycles, not using contraceptives
- Body Mass Index between 18.5-30.0 kg/m2
- Weight stable (+/- 2 kg) for 6 months
- VO2max of ≥35 ml/kg/min
- Willing to consume provided meals and snacks
Exclusion
- Low Energy Availability in Females Questionnaire (LEAF-Q) score ≥8
- Menstrual disturbances measured by progesterone and self-report
- Using contraceptives (oral contraceptives, injections, intrauterine device, etc.)
- Low Bone Mineral Density (z-score \< -1)
- Routine engagement in mechanical loading exercises
- History of fracture in the previous 6 months
- Recent recovery (within the last 12 months) or still in recovery after eating disorder diagnosis
- Medication use that could affect bone metabolism (e.g., corticosteroids, anticonvulsants, heparin, gonadotropin-releasing hormone agonists)
- Pregnancy or lactation
- Abnormal thyroid-stimulating hormone levels
Key Trial Info
Start Date :
August 24 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 12 2024
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT05341700
Start Date
August 24 2022
End Date
April 12 2024
Last Update
August 19 2025
Active Locations (1)
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1
Virginia Polytechnic Institute and State University
Blacksburg, Virginia, United States, 24061