Status:
UNKNOWN
Uterine Artery Doppler Changes After Vaginal Administration of Isosorbide Mononitrate In Patients With URPL
Lead Sponsor:
Al-Azhar University
Conditions:
Recurrent Pregnancy Loss
Eligibility:
FEMALE
20-35 years
Phase:
EARLY_PHASE1
Brief Summary
compare uterine artery blood flow before and after the administration of Isosorbide mononitrate as a nitric oxide donor during mid secretory phase of menstrual cycle for patients with unexplained recu...
Detailed Description
Recurrent pregnancy loss (RPL) is an important reproductive health issue, because it affects 2%-5% of couples. The incidence of RPL varies widely because of the differences in the definitions and crit...
Eligibility Criteria
Inclusion
- Women age: 20-35 years.
- History of recurrent abortion (two or more successive spontaneous abortions) with :
- Normal HSG or hysteroscopy
- Normal serum PRL,
- Normal thyroid function,
- Normal HbA1c,
- Normal pelvic ultrasound
- Negative tests for antiphospholipid antibody syndrome (ACL, Lupus anticoagulant and anti B2 glycoprotein 1) Non pregnant state. Regular menstrual cycles for the previous three months before the study. No hormonal contraception or intrauterine devices. Not on any vasodilator drugs.
Exclusion
- Age less or more than 20-35. Nulligravidae or nullipara. Infertile women. Induced abortion. Systemic diseases that might affect the hemodynamic indices as thrombocytopenia and thyrotoxicosis.
- Cases with uterine anomalies, uterine myomas, polypi and adnexal masses. History of oophorectomy. History of consanguinity. Family history of chromosomal abnormality as Down syndrome and Turner syndrome.
Key Trial Info
Start Date :
May 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2022
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05341856
Start Date
May 1 2022
End Date
September 1 2022
Last Update
April 22 2022
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