Status:
COMPLETED
Transcranial Direct and Alternating Stimulation of the Prefrontal Cortex for Cognitive Improvement in Schizophrenia
Lead Sponsor:
The National Brain Mapping Laboratory (NBML)
Collaborating Sponsors:
Ardabil University of Medical Sciences
Leibniz Research Centre for Working Environment and Human Factors
Conditions:
Schizophrenia
Cognitive Dysfunction
Eligibility:
All Genders
18-50 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to investigate different stimulation intensities and frequencies of transcranial direct and alternating current stimulation over the dorsolateral prefrontal cortex for cog...
Detailed Description
In this randomized, double-blind study, 50 patients diagnosed with schizophrenia are randomly assigned into two arms. The first group receives transcranial direct current stimulation (tDCS) at three i...
Eligibility Criteria
Inclusion
- Diagnosis of schizophrenia based on DSM V,
- Being 18-50 years old (male and female)
- If female, negative urine pregnancy test
- feasibility for tDCS interventions according to safety guidelines
- stable medication regime especially the classical neuroleptics and all CNS-activating medications, if taken, 4-6 weeks before the experiment
- fluency in the native language
- right-handed
- Required written informed consent signed by patients' guardian
Exclusion
- pregnancy
- alcohol or substance dependence
- history of seizure
- history of neurological disorder
- history of head injury
- Presence of ferromagnetic objects in the body that are contraindicated for brain stimulation of the head (pacemakers or other implanted electrical devices, brain stimulators, some types of dental implants, aneurysm clips, metallic prostheses, permanent eyeliner, implanted delivery pump, or shrapnel fragments) or fear of enclosed spaces).
Key Trial Info
Start Date :
April 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2022
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT05342727
Start Date
April 1 2021
End Date
July 31 2022
Last Update
August 8 2022
Active Locations (1)
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1
Ardabil University of Medical Sciences
Ardabil, Iran