Status:
COMPLETED
Long-term Effect of Moderate and Vigorous Exercise on Incident Diabetes in Obese Subjects
Lead Sponsor:
Shanghai Zhongshan Hospital
Conditions:
Type 2 Diabetes
Obesity, Abdominal
Eligibility:
All Genders
40-65 years
Brief Summary
Our previous randomized controlled trial has recruited 220 subjects with central obesity and allocated the subjects to the non-exercise control, moderate exercise and vigorous exercise groups. The pur...
Detailed Description
Our previous randomized controlled trial has recruited 220 subject with central obesity and NAFLD. Those subjects were allocated into non-exercise control, moderate exercise and vigorous exercise grou...
Eligibility Criteria
Inclusion
- Inclusion criteria
- Subjects with NAFLD determined by 1H MRS (intrahepatic triglyceride content ≥5%);
- 40-65 years old;
- Waist circumference \>90cm for men and \>85cm for women
- Exclusion criteria
- Consumed more than an average of 140 grams of ethanol (10 alcoholic drinks) per week in men and 70 grams of ethanol (five drinks) in women during the past six months;
- A history of acute or chronic viral hepatitis, drug-induced liver diseases, and autoimmune hepatitis;
- Myocardial infarction in the past six months;
- Biliary obstructive diseases;
- Uncontrolled hypertension (i.e. systolic BP\>180 mmHg, and/or diastolic DBP \>100 mmHg);
- Chronic kidney disease (serum creatinine ≥1.5 mg/dL in men and ≥1.3 mg/dL in women);
- Heart failure (New York Heart Association III or IV);
- Currently participating in weight loss programs;
- Currently pregnant or planning to be pregnant;
- Having any medical condition that would affect metabolism (i.e. diabetes, known hyperthyroidism or hypothyroidism);
- Having a medical condition that would limit exercise participation and taking medication that would affect metabolism or weight loss (i.e. thyroid medication and glucocorticoids) or would alter the heart rate response during exercise (i.e. β-blockers);
- Unable to participate in the follow-up examination.
Exclusion
Key Trial Info
Start Date :
July 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 30 2022
Estimated Enrollment :
220 Patients enrolled
Trial Details
Trial ID
NCT05346250
Start Date
July 1 2011
End Date
May 30 2022
Last Update
June 7 2023
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