Status:
COMPLETED
Methylglyoxal Evaluation in Humans
Lead Sponsor:
University of Kansas Medical Center
Conditions:
Type 2 Diabetes
Neuropathy, Painful
Eligibility:
All Genders
45-75 years
Brief Summary
The investigators will test the hypothesis that patients with low back pain associated with lumbar disc aberrancy will have elevated MGO-protein levels circulating in the blood that are comparable to ...
Detailed Description
This is a cross-sectional, non-interventional study conducted solely at KU Medical Center in which patients will be recruited and sorted based on the following status: 1) healthy, 2) painful diabetic ...
Eligibility Criteria
Inclusion
- Informed consent provided by the subject
- Able to read/speak English
- TYPE 2 DIABETES
- All healthy inclusion criteria AND
- Blood glucose levels \> 126 mg/dl
- Diagnosed with neuropathy or experience painful numbness or tingling in their hands or feet
- LOW BACK PAIN
- All healthy inclusion criteria AND
- Chronic (persistent pain lasting longer than 3 months) low back pain as a direct result of non-operative lumbar disc aberrancy (disc herniation, protrusion, or extrusion)
- Aberrancy occurring within 12 months of pre-screening
Exclusion
- Prisoner
- Current clinically significant cardiac or neurological disease
- Diagnosis of IBS, osteoarthritis, fibromyalgia, complex regional pain syndrome (CRPS), postherpetic neuralgia
- Lumbar surgery due to disc aberrancy
- Therapeutic spinal injections within the last 3 months (steroid, ablations, etc.)
- Chronic use of steroids or non
- steroidal anti-inflammatory drugs (NSAIDS) within 3 months of pre-screen
- Past or present use of spinal cord stimulators
Key Trial Info
Start Date :
May 2 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2025
Estimated Enrollment :
39 Patients enrolled
Trial Details
Trial ID
NCT05350553
Start Date
May 2 2022
End Date
April 1 2025
Last Update
April 4 2025
Active Locations (1)
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1
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160