Status:
RECRUITING
Intrathecal Morphine for Analgesia in Video-assisted and Robotic-assisted Thoracic Surgery
Lead Sponsor:
Northwestern University
Conditions:
Pain, Postoperative
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
VATS/RATS is widely used for diagnosis and treatment of intrathoracic conditions. Despite many benefits, postoperative pain continues to be intense after VATS/RATS. The optimal strategy for pain manag...
Detailed Description
This is a randomized, placebo-controlled, double-blinded clinical trial. Patients will be randomized into one of two groups. Group A (Placebo, control group) will receive intrathecal sterile normal sa...
Eligibility Criteria
Inclusion
- Age 18-80 years old
- Undergoing elective video-assisted thoracoscopic or robotic assisted surgery for anatomical lung resection
- General anesthesia with anticipated intraoperative extubation.
Exclusion
- American Society of Anesthesiologists (ASA) classification of 4 or 5
- Anticipated postoperative intubation
- Significant liver disease
- Preoperative use of intravenous inotropes and/or vasopressor support
- Preoperative mechanical ventilation
- Preoperative use of mechanical circulatory support device (intraaortic balloon pump, ventricular assist device, extracorporeal membrane oxygenation)
- Severe pulmonary disease (home oxygen requirement and/or current oral steroid use)
- Morphine allergy
- Opioid or alcohol abuse
- Chronic pain
- Renal failure
- Inability to comprehend English language
- Bleeding disorder
- Abnormal preoperative coagulation
- Infection
- Patient refusal
- Failed spinal
Key Trial Info
Start Date :
September 29 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2026
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT05351229
Start Date
September 29 2023
End Date
September 1 2026
Last Update
December 17 2025
Active Locations (1)
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1
University of Chicago
Chicago, Illinois, United States, 60637