Status:
RECRUITING
3DPCT Combined With CT Guided RISI in the Treatment of Thoracic Malignant Tumors
Lead Sponsor:
Peking University Third Hospital
Conditions:
Radioactive Iodine-125 Brachytherapy
Thoracic Cancer
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The main technical difficulties in radioactive iodine-125 seed implantation (RISI) lie in the complexity of operation and the control of operation quality. The current data shows that under the combin...
Eligibility Criteria
Inclusion
- Pathological diagnosis of malignant tumor of chest, lesion diameter less than 7 cm.
- There is no extensive systemic metastasis or although there is metastasis, the metastasis have been controlled by early treatment.
- No bleeding tendency, anticoagulant therapy and / or antiplatelet coagulation drugs should be stopped for at least 1 week before treatment.
- No serious or uncontrolled underlying diseases (such as severe or uncontrolled hypertension, diabetes, cardiovascular and cerebrovascular diseases and organ dysfunction) are found.
- There is a suitable puncture path, and the therapeutic dose is expected to be achieved.
- KPS \> 70, expected to tolerate puncture / seed implantation, and expected survival time greater than 3 months.
Exclusion
- Severe impairment of lung function (such as FEV1 \< 40% predicted value, FVC \< 50% predicted value, DLCO \< 40% predicted value).
- High risk of skin invasion and ulceration at the puncture site before treatment.
- There is a large range of liquefaction and necrosis in the lesion, and the expected seed distribution would be poor.
- Pregnant women, lactating women and mentally ill patients.
- The patient with poor compliance and unable to complete the treatment.
- Other conditions of the researchers who think it is not suitable to participate in this clinical trial.
Key Trial Info
Start Date :
May 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 30 2026
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05351268
Start Date
May 1 2022
End Date
April 30 2026
Last Update
December 20 2023
Active Locations (1)
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1
Peking University Third Hospital
Beijing, Beijing Municipality, China, 100191