Status:
RECRUITING
Exercise Training and Fat Metabolism in Postmenopausal Women
Lead Sponsor:
Florida State University
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Pennington Biomedical Research Center
Conditions:
Postmenopausal Symptoms
Obesity
Eligibility:
FEMALE
50-75 years
Phase:
NA
Brief Summary
Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-re...
Detailed Description
The primary objective is to compare the effects of 12 weeks of resistance training to endurance training with respect to whole-body and regional lipolytic (fat breakdown) responses to acute walking ex...
Eligibility Criteria
Inclusion
- Women
- Postmenopausal (50-75 yrs.)
- Obese (BMI 30-50 kg/m2)
- Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg/dL, or 2hr OGTT blood glucose 140 to 199 mg/dL)
- Sedentary (not performing purposeful exercise training more than 20 minutes per day twice a week)
- Non-smokers
- No hormone replacement therapy for at least the past two years.
Exclusion
- Engaging in purposeful resistance training or endurance training (\> 20min/day, \> 2 days/week)
- Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic
- Type 1 or type 2 diabetes
- Medical problems in which exercise is contraindicated, such as chronic infections
- History of, or currently presentation with, cancer, cardiovascular or respiratory disease
- Uncontrolled thyroid dysfunction, liver or renal dysfunction
- Taking any medication affecting lipid metabolism
- Musculoskeletal disease or injury that would otherwise prevent engagement in resistance and endurance training
- Smokers and those with diagnosed eating disorders
Key Trial Info
Start Date :
May 20 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 30 2027
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT05351476
Start Date
May 20 2022
End Date
April 30 2027
Last Update
April 8 2025
Active Locations (1)
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1
Florida State University
Tallahassee, Florida, United States, 32306