Status:
RECRUITING
Psilocybin Therapy for Chronic Low Back Pain
Lead Sponsor:
Joshua Woolley, MD, PhD
Conditions:
Chronic Low-back Pain
Eligibility:
All Genders
25-70 years
Phase:
PHASE1
PHASE2
Brief Summary
This study evaluates whether psilocybin therapy helps patients cope with chronic low back pain more effectively. Patients may be recruited at Stanford and University of California San Francisco (UCSF)...
Detailed Description
Chronic pain is associated with higher levels of pain-related distress, depression, emotional dysfunction, helplessness, hopelessness, and suicidality. Psilocybin is a psychoactive drug that may be we...
Eligibility Criteria
Inclusion
- Age 25 to 70 years old
- Comfortable speaking and writing in English
- Diagnosed with chronic low back pain
- Able to attend all in-person visits at UCSF as well as virtual visits
- Has tried at least two previous medications/ procedures and physical therapy trials for low back pain
Exclusion
- Chronic low back pain that is attributed to malignancy, subacute or acute fracture or infection
- Low back pain with radiation below the knee
- Low back pain with neurologic signs present
- Regular use of medications that may have problematic interactions with psilocybin, including but not limited to dopamine agonists, MAO inhibitors, antipsychotics, and stimulants
- A health condition that makes study unsafe or unfeasible, determined by study physicians
Key Trial Info
Start Date :
December 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2026
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05351541
Start Date
December 1 2023
End Date
April 1 2026
Last Update
March 20 2025
Active Locations (1)
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1
University of California San Francisco
San Francisco, California, United States, 94107