Status:
RECRUITING
STOPS Trial: Total vs Subtotal Colectomy for Slow Transit Constipation
Lead Sponsor:
Third Military Medical University
Conditions:
Slow Transit Constipation
Surgery
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Total colectomy with ileorectal anastomosis is a traditional surgical option for slow transit constipation (STC). Subtotal colectomy with caecorectal anastomosis have been reported to be a potential a...
Detailed Description
Constipation, a prevalent gastrointestinal disorder, affects 10%-15% of adults in the United States and approximately 8.2% of China's general population. Slow transit constipation (STC), accounting fo...
Eligibility Criteria
Inclusion
- Inclusion criteria
- Patients (≥18 years of age) of either sex
- Patients with conditions in agreement with the Roman IV criteria of functional constipation
- Patients have less than one complete spontaneous bowel movement per week
- Patients rely on laxatives to assist defecation for a long time
- More than 20% the radio-paque markers localized in the colon after 72 hours based on colonic transit studies
- Patients were refractory to conservative treatment for more than 1 year
- Patients with a strong desire for surgery
- Exclusion criteria
- Pregnant or breast-feeding women
- Patients with megacolon, megarectum,severe spastic constipation, severe rectocele, rectal prolapse (Oxford Grade IV or above)
- Patients with colorectal neoplasms
- Patients with small intestinal slow transit
- Patients with constipation-predominant irritable bowel syndrome
- Patients with inflammatory bowel disease
- Patients with ileostomy
- Patients with severe psychiatric disease
Exclusion
Key Trial Info
Start Date :
March 27 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2028
Estimated Enrollment :
252 Patients enrolled
Trial Details
Trial ID
NCT05352074
Start Date
March 27 2022
End Date
December 31 2028
Last Update
March 21 2025
Active Locations (16)
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1
Army Medical Center (Daping Hospital)
Yuzhong, Chongqing Municipality, China, 400042
2
No. 940 Hospital of Joint Logistics Support Force of Chinese People's Liberation Army
Lanzhou, Gansu, China, 730050
3
The People's Hospital of Guangxi Zhuang Autonomous Region
Nanning, Guangxi, China, 530016
4
The First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China, 150007