Status:
RECRUITING
Neural Correlates of Impulsivity in Idiopathic REM Sleep Behavior Disorder
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Parkinson Disease
Eligibility:
All Genders
50+ years
Brief Summary
This study aims to investigate the neural correlates (structural changes, functional connectivity, and structural connectivity of brain structures in prefrontal cortex and basal ganglia) of impulsivit...
Detailed Description
Background: Excessive impulsivity is an important non-motor symptom of Parkinson's disease (PD), especially for those on dopamine agonist treatment. Dopaminergic dysfunction has been highly correlated...
Eligibility Criteria
Inclusion
- Age-and sex-matched with the groups;
- Being capable of giving informed consent for participation of the study;
- Without a personal history or a family history of PD or RBD;
- A total score on REM Sleep Behavior Questionnaire (RBDQ-HK) less than 19, which is the suggestive cut-off of a diagnosis of RBD;
- Absence of self-report dream enactment behaviors and RSWA as measured by v-PSG
Exclusion
- Having a history of ICD diagnosis or ICD symptom(s) assessed with Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS);
- Presence of narcolepsy or other neurodegenerative diseases (except for PD group) that may give rise to RBD;
- Presence of mood disorder which may have great impact on impulsivity;
- A total score of the Montreal Cognitive Assessment (MOCA) ≤ 22 and the Clinical Dementia Rating (CDR) ≥ 1, indicating dementia;
- Except for early medicated PD patients, if subjects from other groups who are on medication that may induce impulsivity, such as dopaminergic medication, will be excluded;
- Contraindication to MRI (e.g., presence of implants or claustrophobia).
Key Trial Info
Start Date :
January 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
96 Patients enrolled
Trial Details
Trial ID
NCT05353855
Start Date
January 1 2022
End Date
December 31 2024
Last Update
April 19 2024
Active Locations (1)
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1
The Chinese University of Hong Kong
Hong Kong, Hong Kong