Status:
COMPLETED
Type 1 Diabetes and Depression: Role of Brain Glutamate
Lead Sponsor:
Beth Israel Deaconess Medical Center
Conditions:
Type1diabetes
Depressive Symptoms
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
The goal of this study is to examine the effect of chronic and acute hyperglycemia in type 1 diabetes mellitus (T1DM) on brain glutamate levels using magnetic resonance spectroscopy (MRS), and associa...
Detailed Description
The research of this study is focused on elucidating the relationship between the perturbations in glucose metabolism associated with T1DM and the higher prevalence of major depressive episodes in thi...
Eligibility Criteria
Inclusion
- T1DM Subjects:
- 10-25 years duration of T1DM.
- Relatively low levels of complications from diabetes.
Exclusion
- Type 2 diabetes and/or gestational diabetes.
- Other major clinical conditions such as cancer, symptomatic coronary artery disease, (e.g., prior myocardial infarction), stroke, proliferative diabetic retinopathy requiring a laser treatment, clinically significant diabetic nephropathy as evidenced by urinary albumin levels \> 300 mg/day and/or serum creatinine \> 1.5 mg/dl for men and \> 1.4 mg/dl for women, painful or symptomatic neuropathy, and/or diagnosed gastroparesis.
- Current or past history of attention deficit hyperactivity disorder, bipolar disorder, obsessive compulsive disorder, panic disorder, substance dependence or schizophrenia.
- Ethanol dependence and/or nicotine dependence according to Diagnostic and Statistical Manual-IV criteria and heavy smokers according to the Epidemiology of Diabetes Interventions and Complications scale 57.
- Control Subjects:
- Inclusion Criteria:
- No history of T1DM or Major Depressive Disorder.
- Normal fasting blood glucose, HbA1c and hematocrit levels.
Key Trial Info
Start Date :
January 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2014
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT05355285
Start Date
January 1 2011
End Date
November 1 2014
Last Update
May 5 2022
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