Status:
RECRUITING
Risk of Metachronous Findings After Detection of Serrated Lesions and High-grade Dysplasia With Surveillance Delay
Lead Sponsor:
Centre hospitalier de l'Université de Montréal (CHUM)
Conditions:
Colorectal Cancer
Colon Adenoma
Eligibility:
All Genders
45-80 years
Phase:
NA
Brief Summary
The primary aim of this study is to determine the rate of total metachronous advanced neoplasia (TMAN) detection after index detection of serrated lesions (SL) \[sessile serrated polyps (SSPs), tradit...
Detailed Description
Colorectal cancer (CRC) ranks second among worldwide cancer related deaths and third in terms of cancer incidence. Colonoscopy-based screening programs have been established to reduce CRC morbidity an...
Eligibility Criteria
Inclusion
- Patients 45-80 who underwent colonoscopy from 2009 to 2022 at the Montreal University Hospital Center (CHUM) with 1+ SL or HGD detected at index colonoscopy and lacking follow-up within or beyond the surveillance interval recommended by 2020 USMSTF guidelines.
Exclusion
- 1\) Patients with a diagnosis of inflammatory bowel disease;
- 2\) Hereditary CRC syndromes;
- 3\) CRC at index colonoscopy;
- 4\) Serrated polyposis syndrome;
- 5\) Life expectancy too short to benefit from colonoscopy;
- 6\) Follow-up colonoscopy not yet due according to USMSTF guidelines. Patients with concomitant HRA and SL at index will be invited to participate if the index (or last) colonoscopy was performed more than 1 year ago. This is based on the high rates of HRA we identified in our retrospective study posing increased risks for these patients.
Key Trial Info
Start Date :
February 27 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
730 Patients enrolled
Trial Details
Trial ID
NCT05355363
Start Date
February 27 2023
End Date
December 31 2025
Last Update
February 11 2025
Active Locations (1)
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1
Centre Hospitalier de l'Université de Montréal
Montreal, Quebec, Canada