Status:
COMPLETED
Effect of Norepinephrine Administration on Ventricular Systolic Function in Septic Shock
Lead Sponsor:
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions:
Septic Shock
Eligibility:
All Genders
18+ years
Brief Summary
This observational, pharmacological, prospective study aims to assess the improvement of ventricular systolic function mediated by norepinephrine (NE) administration in preload non-responders septic s...
Detailed Description
Norepinephrine (NE) is recommended as first line vasopressor in septic shock. Besides increasing arterial tone and thus arterial pressure, NE improves cardiac output (CO) as a result of two main mecha...
Eligibility Criteria
Inclusion
- less than 6 hours from the diagnosis of septic shock
- ongoing vasopressor therapy by continuous intravenous infusion of norepinephrine
- treating physician's decision to increase norepinephrine dose
Exclusion
- preload responsiveness assessed through dynamic indices
- pregnancy
- myocardial disfunction due to active cardiac disease
- inadequate acoustic window for transthoracic echocardiography
- need for emergency treatment
Key Trial Info
Start Date :
March 10 2022
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 20 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05355961
Start Date
March 10 2022
End Date
May 20 2024
Last Update
May 21 2024
Active Locations (1)
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1
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma, RM, Italy, 00168