Status:
UNKNOWN
Multi-level Molecular Profiling of Peak Performance in Endurance Sports
Lead Sponsor:
Paracelsus Medical University
Collaborating Sponsors:
Department of Psychiatry University of Bonn
Conditions:
Exercise
Exercise Test
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
Physical activity triggers complex molecular responses, including changes in immune-, stress-, and metabolic pathways. For example, autophagy is essential for energy and cellular homeostasis through p...
Detailed Description
This is a non-randomized controlled trial performed at the Paracelsus Medical University, Salzburg, Austria. The study will recruit 80 healthy men and women. Subjects who meet the inclusion criteria w...
Eligibility Criteria
Inclusion
- All arms: ability to give written informed consent
- Arms 1- 3: inconspicuous medical examination (medical history, resting ECG, echocardiography)
- Elite athletes (arm1, cyclists): maximum oxygen uptake \> 65 ml/kg/KG
- Elite athletes (arm1, cyclists): participation in cycling competitions on a regular basis
- Recreational athletes (arms 2 and 3): maximum oxygen uptake \< 65 ml/kg/KG for male subjects and \< 55 ml/kg/KG for female subjects
Exclusion
- All arms: unable to communicate adequately by language
- All arms: regular use of prescription drugs other than thyroxine or antihistamines
- All arms: alcohol consumption as equivalent doses averaging more than 40 g of pure alcohol per day
- All arms: use of illicit drugs
- All arms: known diseases of the cardiovascular system
- All arms: arterial hypertension over 160/90 mmHg at rest
- All arms: known pulmonary diseases, especially bronchial asthma
- All arms: surgery less than 4-6 months ago.
- All arms: abnormalities in the medical examination (medical history, resting ECG, echocardiography)
- Arms 1-3: orthopaedic diseases that preclude maximum exercise on a bicycle ergometer
- Elite athletes (arm1, cyclists): maximum oxygen uptake \< 65 ml/kg/KG
- Recreational athletes (arms 2 and 3): maximum oxygen uptake \> 65 ml/kg/KG for male subjects and \> 55 ml/kg/KG for female subjects
- Arm 3: positive urine ß-HCG
Key Trial Info
Start Date :
October 15 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 15 2022
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT05359744
Start Date
October 15 2021
End Date
October 15 2022
Last Update
May 4 2022
Active Locations (1)
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1
Paracelsus Medical University
Salzburg, Austria, 5020