Status:
RECRUITING
PET-study on the Role of the Reward System in Weight Loss After Bariatric Surgery
Lead Sponsor:
University Medical Center Groningen
Conditions:
Obesity
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Bariatric surgery (BS) is currently the most effective treatment in severe obesity. However, a considerable percentage of patients undergoing BS fail to lose sufficient weight or regain weight after i...
Eligibility Criteria
Inclusion
- Bariatric surgery 24-36 months prior to the study
- Adult (over 18y old)
- Mentally capable to understand the consequences of the procedure and make his or her own choice without coercion
- Able to undergo PET and MRI, according to the investigator's assessment
- Native speaking
- Able to participate in follow-up
- Written informed consent
Exclusion
- Presence of a DSM-IV axis 1 disorder
- The use of drugs that bind to dopamine D2/3 receptors, including various classes of antipsychotics and antidepressants
- History of stroke, brain tumor, Parkinson's Disease or dementia
- History of head trauma with loss of consciousness
- Alcohol or substance abuse in the last 6 months
- Alcohol consumption 24h prior to PET scanning
- Smoking or other forms of nicotine intake 12 hours prior to PET scanning
- Use of anorectic drugs in the last 6 months
- Current pregnancy
- Medication for Diabetes Mellitus
- Claustrophobia
- The presence of implanted metal objects of the type which may concentrate radiofrequency fields or cause tissue damage from twisting in a magnetic field (such as certain implanted devices, shrapnel, ocular metal shavings)
- Patients with a bodyweight \> 200kg will be excluded to ensure the maximum load of the camera bed of the PET-scanner (227 kg) is not exceeded.
Key Trial Info
Start Date :
December 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05359887
Start Date
December 1 2022
End Date
December 31 2024
Last Update
May 14 2024
Active Locations (1)
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1
MCL
Leeuwarden, Netherlands