Decentrialz logo
  • HIPAA Compliant
  • ISO 27001 Certified
Find Trials
About UsContact
Become a Volunteer+1 877 705 1914

Status:

ACTIVE_NOT_RECRUITING

Head-to-Head Harmonization of Tau Tracers in Alzheimer's Disease

Lead Sponsor:

Tharick Pascoal

Collaborating Sponsors:

National Institute on Aging (NIA)

Conditions:

Alzheimer Disease

Eligibility:

All Genders

18-90 years

Phase:

PHASE1

Brief Summary

The purpose of this study is to compare/harmonize cross-sectional and longitudinal tau tangle measurements obtained with the tau PET radiopharmaceuticals Flortaucipir and MK-6240 to elucidate the adva...

Detailed Description

This is a longitudinal, multi-site, non-randomized study in which the participants will undergo Flortaucipir and MK-6240 PET scans at baseline and approximately at 18-month follow-up. At each time poi...

Eligibility Criteria

Inclusion

  • Inclusion criteria:
  • Have a study partner who will be able to provide an independent evaluation of functioning.
  • Willing and capable of undergoing repeated MR/PET imaging.
  • Fluent in a language approved by the coordinating center.
  • At screening, must have no cognitive impairment, or meet criteria for single- or multiple-domain amnestic mild cognitive impairment or Alzheimer's disease dementia.
  • Exclusion criteria:
  • Inability to provide informed consent by self or by proxy.
  • Pregnant or breastfeeding women.
  • Have any condition or are taking any medication that could increase the risk to the participant, limit the ability to tolerate or interfere with the results of the tests and procedures (in the opinion of the investigator).

Exclusion

    Key Trial Info

    Start Date :

    March 2 2022

    Trial Type :

    INTERVENTIONAL

    Allocation :

    ACTUAL

    End Date :

    May 31 2027

    Estimated Enrollment :

    822 Patients enrolled

    Trial Details

    Trial ID

    NCT05361382

    Start Date

    March 2 2022

    End Date

    May 31 2027

    Last Update

    October 29 2025

    Active Locations (9)

    Enter a location and click search to find clinical trials sorted by distance.

    Page 1 of 3 (9 locations)

    1

    Lawrence Berkeley National Laboratory

    Berkeley, California, United States, 94720

    2

    University of California San Francisco

    San Francisco, California, United States, 94143

    3

    Mayo Clinic

    Rochester, Minnesota, United States, 55905

    4

    Washington University in St. Louis

    St Louis, Missouri, United States, 63130