Status:
RECRUITING
Effect of Intensive LDL-cholesterol Targeting for Elderly Patients With Cardiovascular Disease: I-OLD Trial
Lead Sponsor:
Yonsei University
Conditions:
Cardiovascular Disease
Eligibility:
All Genders
75+ years
Phase:
PHASE4
Brief Summary
Although there have been studies regarding intensive lowering of low-density lipoprotein (LDL)-cholesterol with high intensity statins in patients with cardiovascular disease, elderly patients were ei...
Eligibility Criteria
Inclusion
- Age ≥75 years
- Documented cardiovascular disease (at least 1 of the following) A. Previous acute coronary syndrome (MI or unstable angina) B. Or stable angina with imaging studies of coronary artery disease or functional studies of myocardial ischemia C. Or coronary revascularization (percutaneous coronary intervention or coronary artery bypass graft) D. Or peripheral artery disease.
Exclusion
- MI or stroke within 1 year
- LDL-cholesterol level less than 55 mg/dL without statin therapy
- Active liver disease or persistent unexplained serum AST/ALT elevation more than 2 times the upper limit of normal range
- Allergy or hypersensitivity to any statin
- Life expectancy less than 1 years
- Inability to follow the patient over the period of 1 year after enrollment, as assessed by the investigator
Key Trial Info
Start Date :
July 19 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 15 2027
Estimated Enrollment :
1200 Patients enrolled
Trial Details
Trial ID
NCT05361421
Start Date
July 19 2022
End Date
October 15 2027
Last Update
March 15 2024
Active Locations (1)
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1
Yonsei University Health System, Severance Hospital
Seoul, South Korea