Status:
RECRUITING
A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies
Lead Sponsor:
MacroGenics
Conditions:
Leukemia, Acute Myeloid
Myelodysplastic Syndromes
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
CP-MGD024-01 is a Phase 1, open-label, multi-center study of MGD024 as a single agent in participants with select blood cancers that have not responded to treatment with standard therapies or who have...
Eligibility Criteria
Inclusion
- Adult patients at least 18 years of age, able to provide informed consent and willing to comply with all study procedures.
- Participants with
- primary or secondary acute myeloid leukemia (AML) except acute promyelocytic leukemia,
- primary or secondary myelodysplastic syndrome (MDS) with prognostic score of \>3 and \<20% bone marrow blasts,
- classical Hodgkin lymphoma (cHL),
- chronic myelogenous leukemia (CML),
- b-cell acute lymphocytic leukemia (B-ALL),
- hariy cell leukemia (HCL),
- advanced systemic mastocytosis (ASM), or
- blastic plasmacytoid dendritic cell neoplasm (BPDCM)
- Relapsed after or refractory to at least one prior line of therapy and with no available potentially curative treatment option.
- Evidence of at least 20% of malignant cells with CD123 expression.
- Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 2.
- Life expectancy of at least 12 weeks.
- Acceptable laboratory values, and heart function.
- Continuing side effects of prior treatment are mild
- Women and men of childbearing potential must agree to use highly effective forms of contraception throughout the study through 4 months after the last dose of MGD024.
Exclusion
- Prior treatment with an anti-CD123-directed agent (except patients with BPDCN, who are allowed to have received prior tagraxofusp).
- Known involvement of central nervous system (CNS) by the disease under investigation.
- History or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the patient's participation for the full duration of the trial, or is not in the best interest of the patient.
- Systemic anti-cancer therapy, investigational therapy, corticosteroids or other immune suppressive drugs within 14 days of first dose
- Vaccination with any live virus vaccine within 4 weeks prior to first dose. Inactivated annual influenza and SARS-CoV-2 vaccination are allowed.
Key Trial Info
Start Date :
July 13 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2027
Estimated Enrollment :
130 Patients enrolled
Trial Details
Trial ID
NCT05362773
Start Date
July 13 2022
End Date
May 1 2027
Last Update
October 30 2025
Active Locations (7)
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1
Colorado Blood Cancer Network
Denver, Colorado, United States, 80218
2
University of Maryland, Greenbaum Comprehensive Cancer Center
Baltimore, Maryland, United States, 21201
3
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02215
4
START - Midwest
Grand Rapids, Michigan, United States, 49503