Status:
UNKNOWN
Different Induction Protocols in PCOS After Clomiphene Citrate Failed Pregnancy in Non-IVF Cycles
Lead Sponsor:
Menoufia University
Conditions:
Infertility, Female
Eligibility:
FEMALE
Phase:
PHASE4
Brief Summary
The aim of this study will be to compare between 4 different induction protocols in women who: 1. Failed to achieve ovulation after clomiphene citrate treatment at a dose of 150mg daily (if the patie...
Detailed Description
The study will include 4 treatment groups: GROUP 1: Participants of this group will receive Letrozol (Femara, Novartis) at a dose of 2.5mg twice daily starting from day 3 of the cycle for 5 days. GR...
Eligibility Criteria
Inclusion
- Women aged between 20-35 years
- Body mass index ≤ 30
- Primary or secondary infertility for ≥1 year due to PCOS (diagnosed based on Rotterdam criteria which require the presence of two of the following: Oligo\\an ovulation , hyperandrogenism, polycystic ovaries on ultrasound)
- Failure to achieve ovulation after clomiphene citrate treatment at a dose of 150mg daily (if the patient can tolerate this dose) for 5 days for 3 cycles or only 100 mg daily for the same duration (if she can't tolerate higher dose)
- Failure to achieve pregnancy after 3 cycles of ultrasound indicated ovulation with clomiphene citrate treatment at a dose of 100mg or 150mg daily.
- Day-2 follicle-stimulating hormone less than 12 IU/ml
- Normal serum prolactin and thyroid function
- Normal uterine cavity
- At least one patent tube
- Male partner with normal semen count and motility according to WHO criteria
Exclusion
- Male factor infertility
- Bilateral tubal block
- Uncontrolled thyroid dysfunction
- Uterine factor of infertility.
- Known cases with endometriosis.
Key Trial Info
Start Date :
June 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2023
Estimated Enrollment :
176 Patients enrolled
Trial Details
Trial ID
NCT05362799
Start Date
June 1 2022
End Date
December 31 2023
Last Update
May 5 2022
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